Christopher G. R. Perry

Associate Professor

Locations / Contact Info:

341 Norman Bethune College - BC
Keele Campus
Phone: 416-736-2100 Ext. 33232

Email address(es):

cperry@yorku.ca

Faculty & School/Dept.

Faculty of Health - School of Kinesiology & Health Science

Degrees

BSc - 2002
University of Guelph
Guelph

MSc - 2003
University of Guelph
Guelph

PhD - 2008
University of Guelph
Guelph

Selected Publications

Last 5 years. * denotes equal contribution



Monaco CMF, Perry CGR, Hawke TJ. Alterations in mitochondrial functions and morphology in muscle and non-muscle tissues in type 1 diabetes: implications for metabolic health. Exp Physiol. 2019 December 9, Accepted.



Monaco CMF, Bellissimo C, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ. Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol: Endocrinol Metab. 2020 January 1; 318(1):E44-E51.



Islam H, Bonafiglia JT, Turnbull PC, Simpson CA, Perry CGR, Gurd BJ. The impact of acute and chronic exercise on Nrf2 expression in relation to markers of mitochondrial biogenesis in human skeletal muscle. Eur J Appl Physiol. 2020 January; 120(1): 149-160.



Turnbull PC, Dehghani AC, Theriau CF, Connor MK, Perry CGR. Synergistic activation of mitochondrial metabolism and the glutathione redox couple protects HepG2 hepatocarcinoma cells from palmitoylcarnitine-induced stress. Am J Physiol: Cell Physiol. 2019 December 1; 317(6): C1324-C1329.



Turnbull PC, Hughes, MC, Perry CGR. The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol: Cell Physiol. 2019 December 1; 317(6): C1278-1288.



·       - Chosen by Editors: highlighted for distinction in scholarship in APS Select (https://www.physiology.org/apsselect/about)



Polidovitch N, Yang S, Sun H, Ahmad F, Gao X, Turnbull PC, Chiarello C, Perry CGR, Manganiello V, Yang P, Backx PH. Phosphodiesterase type 3A (PDE3A), but not type 3B (PDE3B), contributes to the adverse cardiac remodeling induced by pressure overload. J Mol Cell Cardiol, 2019 July; 132: 60-70.



Hughes MC*, Ramos SV*, Turnbull PC, Edgett BA, Huber JS, Polidovitch N, Schlattner U, Backx PH, Simpson JA, Perry CGR. Impairments in left ventricular mitochondrial bioenergetics precede overt cardiac dysfunction and remodeling in Duchenne muscular dystrophy. J Physiol, 2019 Jan 22 (In Press).



Hughes MC*, Ramos SV*, Turnbull PC, Rebalka IA, Cao A, Monaco CMF, Varah NE, Edgett BA, Huber JS, Tadi P, Delfinis LJ, Schlattner U, Simpson JA, Hawke TJ, Perry CGR. Early myopathy in Duchenne muscular dystrophy is associated with elevated mitochondrial H2O2 emission during impaired oxidative phosphorylation. Journal of Cachexia, Sarcopenia and Muscle. 2019 June, 10: 643-661.



Ramos SV*, Hughes MC*, Perry CGR. Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies. Am J Physiol: Cell Physiol. 2019 Mar 1; 216(3): C449-C455.



Rudnicki M, Abdifarkosh G, Nwadozi E, Ramos SV, Makki A, Sepa-Kish DM, Ceddia RB, Perry CGR, Roudier E, Haas TL. Endothelial-specific Foxo1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth. eLife 2018 Dec 4; 7. pii. e39780



Bellissimo C, Perry CGR. Sex differences in the regulation of hepatic mitochondrial turnover following physical activity: do males need more quality control than females? J Physiol. 2018 Dec; 596(24): 6125-6126. (Invited perspectives)



Monaco CMF*, Hughes MC*, Ramos SV, Varah NE, Lambzerz C, Rahman FA, McGlory C, Tarnopolsky MA, Krause MP, Laham R, Hawke TJ*, Perry CGR*. Altered mitochondrial bioenergetics and ultrastructure in the skeletal muscle of young adults with type 1 diabetes. Diabetologia. 2018 June; 61(6): 1411-1423. *These authors contributed equally to this investigation.



Song E., Ramos SV, Huang X, Liu Y, Botta A, Sung H, Turnbull P, Wheeler M, Berger T, Wilson D, Perry CGR, Mak TW, Sweeney G. Holo-Lipoclain-2 derived siderophores increase mitochondrial ROS and impair oxidative phosphorylation in rat cardiomyocytes. Proceedings of the National Academy of Sciences. 2018 Feb 13; 115(7): 1576-1581.



Pinho RA, Sepa-Kishi DM, Bikopoulos G, Wu MV, Uthayakumar A, Mohasses A, Hughes MC, Perry CGR, Ceddia RB. High-fat diet induces muscle oxidative stress in a fiber type-dependent manner. Free Radical Biology and Medicine (IF: 5.7). Accepted July 2017. FRBM-D-17-00238R1.



Monaco CMF, Perry CGR, Hawke TJ. Diabetic Myopathy - Current Molecular Understanding of this Novel Neuromuscular Disorder. Current Opinion in Neurology. Accepted June 2017. WCO300502



Perry CGR and Hawley JA. Molecular Basis of Exercise-Induced Skeletal Muscle Mitochondrial Biogenesis: Historical Advances, Current Knowledge, and Future Challenges. Invited review in ‘The Biology of Exercise’, Cold Harbor Springs Perspectives in Medicine. 2017 May 15: pii: a029686.



Mandel ER, Dunford EC, Abdifarkosh G, Turnbull PC, Perry CGR, Riddell MC, Haas TL. The superoxide dismutase mimetic Tempol does not alleviate glucocorticoid-mediated rarefaction of rat skeletal muscle capillaries. Physiological Reports. 2017 May 5(10): pii: e13243.



Perry CGR. Mitochondrial adaptations to exercise in human skeletal muscle: a possible role for cristae density as a determinant of muscle fitness. J Physiol. May 1: 595(9): 2773-2774, 2017. (Invited Perspectives)



Bhattacharya D, Ydfors M, Hughes MC, Norrbom J, Perry CGR, Scimè A. Decreased transcriptional co-repressor p107 is associated with exercise-induced mitochondrial biogenesis in human skeletal muscle. Physiological Reports. Mar 5(5). Pii: e13155, 2017.



Porras DP, Abbaszadeh M, Bhattacharya D, D’Sousa NC, Edjiu N, Perry CGR, Scimè A. p107 determines a metabolic checkpoint required for adipocyte lineage fates. Stem Cells. May: 35(5): 1378-1397, 2017.



Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Motillo EP, Perry CGR, Kemp BE, Tarnopolsky MA, Steinberg GR. Salsalate (salicylate) uncouples mitochondria, improves glucose homeostasis, and reduces liver lipids independent of AMPK β1. Diabetes. Nov: 65(11): 3352-3361, 2016.



MacPherson RE, Dragos SM, Ramos S, Sutton C, Frendo-Cumbo S, Castellani L, Watt MJ, Perry CGR, Mutch DM, Wright DC. Reduced ATGL-mediated lipolysis attenuates beta adrenergic induced AMPK signaling but not the induction of PKA targeted genes in adipocytes and adipose. Am J Physiol Cell Physiol. Aug 1: 311(2): C269-76, 2016.



Edgett BA, Hughes MC, Matusiak JBL, Perry CGR, Simpson CA, Gurd BJ. SIRT3 gene expression but not subcellular localization is altered in response to fasting and exercise in human skeletal muscle. Exp Physiol. Aug 1: 101(8): 1101-13, 2016.



Perry CGR, Wright DC. 2016. Challenging dogma: Is hepatic lipid accumulation in Type 2 Diabetes due to mitochondrial dysfunction? J Physiol. Aug 1: 594(15): 4093-4094, 2016. (Invited Perspectives)



Edgett BA, Scribbans TD, Raleigh JP, Matusiak JBL, Boonstra K, Simpson CA, Perry CGR, Quadrilatero J, Gurd BJ.  The impact of a 48-hour fast on SIRT1 and GCN5 in human skeletal muscle. Appl Physiol Nutr Metab. Sept: 41(9): 953-62, 2016.



Ydfors M*, Hughes MC*, Laham R, Schlattner U, Norrbom J, Perry CGR. Modeling in vivo creatine/phosphocreatine in vitro reveal divergent adaptations in human muscle mitochondrial respiratory control by ADP post-exercise.  J Physiol. Jun 1: 594(11): 3127-40, 2016. *These authors contributed equally to this investigation.



Hughes MC, Ramos SV, Turnbull PC, Nejatbakhsh A, Baechler BL, Tahmasebi H, Laham R, Gurd BJ, Quadrilatero J, Kane DA, Perry CGR. Mitochondrial bioenergetics and fibre type assessments in microbiopsy vs Bergstrom percutaneous sampling of human skeletal muscle. Frontiers in Physiology. Dec 18;6:360, 2015.



Castellani L, Perry CGR, MacPherson R, Root-McCaig J, Huber J, Arkell A, Simpson J, Wright DC. Exercise mediated IL-6 signaling occurs independent of inflammation and is amplified by training in mouse adipose tissue.  JAPPL. Dec 1;119(11):1347-54, 2015. 



 



 


Other Research Outputs

Affiliations

Canadian Society of Exercise Physiology
Director Academic, Board of Directors 2015-2019; Member, Membership Services Committee since 2019 - Focused on developing awards, grants and other initiatives that enhance the research and practice of exercise physiology in Canada with the ultimate goal of promoting physical activity and health in Canadians

American Physiological Society
Reviewing Editor for American Journal of Physiology: Cell Physiology; Reviewing Editor for American Journal of Physiology: Endocrinology and Metabolism; Reviewing Editor for Journal of Applied Physiology Thematic review editor activities

Muscle Health Research Centre, Faculty of Health, York University
Member of the Executive. - Focused on research-enhancing activities through the MHRC.

Canadian Oxidative Stress Consortium
Member of the Executive panel. - Focused on organizing the biennial COSC meeting and developing a network of Canadian researchers focused on broad topics and applications in oxidative stress.

MitoNET
Leader, Bioenergetics Pillar. - Working with a panel of researchers and MitoCanada (mitocanada.org) to grow a national network of researchers, clinicians and patients to promote new therapies and diagnostics for mitochondrial diseases.

Partnerships

Multiple industry partners focused on developing metabolic enhancing compounds for treatment of muscle disorders

Service/Community Activities

Applied Physiology, Nutrition and Metabolism - Journal
Associate Editor

Participate in public education forums through various institutions
Provide lectures to public. Topics focus on understanding the role of skeletal muscle health as a modifier of risks for diseases and disorders.

Awards

Dean’s Award for Excellence in Research: Early Career - 2017

Dean's Award for Excellence in Service to the University and Community - 2019

York Research Leader - 2019

Supervision

Currently available to supervise graduate students: Yes

Currently taking on work-study students, Graduate Assistants or Volunteers: Not Indicated

Available to supervise undergraduate thesis projects: Yes

Current Research

Our laboratory investigates the regulation of skeletal muscle metabolism. Under this umbrella, we explore how a loss of normal metabolic regulation contributes to diseases that cause muscle weakness and limit exercise capacity. A major goal of our program is to develop novel therapeutic strategies to enhance and restore normal metabolic control and improve muscle fitness in disorders such as Duchenne muscular dystrophy as well as cancer and chemotherapy-induced muscle weakness.  We also apply this expertise to disrupt, rather than enhance, metabolism in cancer to slow tumour growth. Through collaboration, we apply our expertise to understanding muscle health in other conditions such as Type 1 Diabetes and other disorders.

Using a suite of human muscle biopsies, preclinical rodent models and cell culture, our approaches integrate direct measures of muscle fitness in skeletal muscle and diaphragm, diagnostic imaging of muscle volume and sub-cellular assessments of energy homeostasis. A major emphasis is placed on the regulation of mitochondrial bioenergetics as a central regulator of energy provision, oxidative stress and calcium homeostasis, and the manner by which these critical functions influence muscle function and mass.

We apply our mechanistic discoveries to developing therapies that improve muscle fitness through collaboration with international pharmaceutical partners and by modifying exercise therapy regimens within the constraints of specific disorders.

Our laboratory environment is enriched with multiple collaborations in diverse fields that span basic and applied sciences. We routinely host visiting trainees and share our mitochondrial bioenergetic and modified human muscle biopsy methodologies with laboratories across Canada, USA, Europe and Australia as well as through instructor roles at specialized international training workshops.

Our program is supported by NSERC Discovery, NSERC RTI, CFI/ORF, the James H Cummings Foundation and the Rare Disease Foundation.

Research Projects

Targeting mitochondria to treat muscle weakness in Duchenne muscular dystrophy
We are testing novel metabolic enhancer therapies to restore healthy metabolism in muscle and slow muscle weakness in this debilitating disease.
Role: Principal Investigator
Funded by: Other...

Targeting mitochondria to treat cachexia during cancer
We are testing novel mitochondrial-targeted therapies to enhance metabolism and slow the development of muscle weakness during cancer.
Role: Principal Investigator
Funded by: Other...

Skeletal muscle metabolism in type 1 diabetes
In collaboration with Dr. Thomas Hawke at McMaster University, we are participating in their research on identifying skeletal muscle metabolic abnormalities in people with type 1 diabetes. This foundation will work is focused on supporting future therapeutic interventions to restore healthy metabolism as part of a strategy for regulating glycemia in this disease.
Role: Collaborator
Funded by: Other...

Disrupting metabolism in cancer to slow tumour growth
We are building on our recent publications that target specific metabolic pathways that generate reactive oxygen species in order to lower glutathione and slow cancer growth.
Role: Collaborator
Funded by: Other...

Curriculum Vitae (C.V. file):

CV of Christopher G. R. Perry